"The best drug discovery organizations don't just run experiments — they reason about biology at scale, and build the infrastructure to act on what they learn." 

-Constantine Kreatsoulas, PhD

    I founded Heuresis Bio on a conviction built over two decades on the front lines of drug discovery: that the gap between a validated target and a clinical candidate is most often a strategy and leadership problem, not a chemistry problem.

 

    My career spans senior leadership roles — including SVP, Head of Research and SVP, Head of Discovery Technology Sciences. I built and led multidisciplinary high performing teams that invented development candidates and clinical assets. I have also built and evolved platforms, encompassing science, strategy, and both the lab and cloud infrastructure to make them succesful.

 

    A recurring thread across my career has been building partnerships that give early-stage science its reach. I have led three alliance formations with top-10 pharma companies end-to-end: generating the science that made each deal attractive, defining scope, budget, and terms, and then serving as the Joint Steering Committee lead upon execution. Those deals spanned collaborations for discovery platform hit ID, first-in-class target lead optimization, and AI technology platform access — each structurally different, but requiring the same combination of scientific credibility and strategic clarity to get done.

 

My current engagements include an active scientific advisory relationship with a clinical stage biotech.